Juan Macalupu, MD
Nominated From: University of Washington
Research Site: Universidad Peruana Cayetano Heredia
Research Area: Blood Banks, Implementation Science
Primary Mentor: Dr. Sarah Gimbel
Research Project
Optimizing healthcare for blood donors potentially affected by transfusion-transmissible infections in the Peruvian Amazon: Pre-implementation study
In the Peruvian Amazon, a significant proportion of blood donors test reactive for HIV, HTLV-I/II, and other transfusion-transmissible infections (TTIs) but receive no further attention. Optimizing healthcare for these individuals in underserved settings can mitigate catastrophic outcomes by enabling early TTI diagnosis and management. Efficient coordination between Blood Bank and Infectious Diseases services is essential to provide comprehensive care for blood donors potentially affected by TTIs. To effectively address this practical problem, an Implementation Science approach is required. Objective: This study aims to design and pilot-assess a feasible, appropriate, and acceptable Innovation to optimize healthcare for blood donors potentially affected by transfusion-transmissible infections in Madre de Dios and Ucayali. Methods: We will conduct a pre-implementation mixed-methods project, following the Consolidated Framework for Implementation Research (CFIR) in the hospitals “Santa Rosa” and “Amazónico”. Using the CFIR, we will focus on the Inner Setting Domain and the Care Continuum to identify contextual determinants and enhance the probability of successful innovation implementation. Specific aim 1: Convergent mixed methods to study the care continuum of blood donors and the inner setting of “Santa Rosa” and “Amazónico” hospitals. Specific aim 2: Qualitative, participatory and formative. Innovation design using the SISGALENPLUS software to integrate Blood Bank and Infectious Diseases services. Specific aim 3: Convergent mixed methods to pilot-assess the feasibility, appropriateness, and acceptability of the designed innovation.
Research Significance
This project will develop an Innovation with the potential to improve the early diagnosis and management of transfusion-transmissible infections, thereby preventing serious health outcomes, contributing to the control of infection transmission, reducing health inequities in underserved populations and improving blood safety in Madre de Dios and Ucayali. In addition, the practical problem addressed by this project is prevalent in other low- and middle-income countries. Consequently, the resulting Innovation from this study can inform future implementation research in similar settings.
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