Mario Cornejo, MD
Nominated From: University of Washington
Research Site: Peru
Research Project: Neurogenetics & Population Genetics
Primary Mentors: Cyrus Zabetian
Target Sequencing Analysis of Parkinson’s Disease Genes in a Native Amerindian Population from Puno-Peru
Parkinson’s disease (PD) is the second most common neurodegenerative disorder with a prevalence of 1-2% in those aged 60 years or older. Human genetic studies have begun to shed light on the molecular events that lead to neuronal injury and recent genome-wide association studies have uncovered over a dozen genes that modify PD risk in populations of European or Asian ancestry. However, the applicability of these results to Latin American populations has not yet been determined because the genetic makeup of these populations is complex and typically includes a substantial proportion of Amerindian admixture.
Although international genetic databases, such as the 1000 genomes project, include small numbers of mestizos (individuals of mixed ancestry) from Latin America (e.g. Puerto Ricans, Mexican Americans, and Colombians) “pure” Amerindians are not included. Furthermore, even small-scale genetic studies in Amerindian populations are limited and no genetic studies of neurodegenerative diseases have been conducted in these individuals.
This project will generate a list of sequence variants and corresponding frequencies for 12 PD-related genes in healthy Quechua Amerindian individuals. These data will then serve as a resource to our group and other investigators conducting future PD genetic studies in Latin American or other populations.
Advice for Potential Applicants
- It is a unique opportunity to get Global Health mentored research experience right in the field, how it will be only depends on you.
- Excellent opportunity to learn about cultural and social aspects in each country. However keep in mind to be respectful to local costumes that might be quite different.
- Your mentoring team, both local and US, will be always happy to help and support you, do not hesitate to contact them if you have any doubt or trouble.
- Pilar Mazzetti, MD, MBA (INCN, Peru)
- Ignacio F. Mata, PhD (UW)
- Cyrus Zabetian, MD, MS (UW)
- Silvia Montano
Meet Dr. Cornejo: