Jonathan Mayito, MBChB, MMed
Nominated From: University of Minnesota
Research Site: Infectious Diseases Institute, Uganda
Research Area: Tuberculosis diagnostics and treatment monitoring
Primary Mentor: Joshua Rhein
Utility of the monocyte to lymphocyte ratio in diagnosing latent tuberculosis among HIV-infected individuals with a negative tuberculosis symptom screen
Evaluating the diagnostic performance of the Monocyte to Lymphocyte ratio (MLR) compared to interferon gamma release assay, and measure the change in MLR from baseline to three months during Tuberculosis Preventive Therapy, among HIV-infected patients with a negative WHO symptom screen.
MLR would offer an alternative biomarker for screening for latent tuberculosis to identify individuals that would more likely benefit from TPT, and to target the preventive therapy to only individuals at utmost risk for active TB.
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