Many grant-supported research activities at Makerere University emphasize a multidisciplinary approach to health and disease (e.g., HHV-8 and malignancy; neurobehavioral sequelae of severe malaria; iron deficiency; severe malaria and neurodevelopment; zoonotic sources of human disease outbreaks; neurologic complications of HIV), making Uganda an outstanding partner for Global Health Fellowship training. NPGH projects in the past have focused on complications of malaria.
Makerere University has strong research collaborations with UW and UMN since 2002 (UW) and 2003 (UMN). These institutions currently partner on 24 active research studies, including 20 NIH-funded studies, and two Fogarty-funded training grants. Areas of research focus include infectious diseases (HIV, malaria, cryptococcal meningitis, herpes viruses, HHV-8, zoonotic diseases), cancer, child development and mental heath, and nutrition.
The UW and UMN D43 training grants in Uganda focus on education in HIV and connections between infection and neurodevelopment. UMN has had grants that included faculty mentor training at Makerere University. UMN One Health Workforce grant was instrumental in creating the One Health Central and East Africa network that includes Uganda which collaborates with the Ugandan Ministry of Health to increase capacity for detecting and responding to disease outbreaks, including zoonotic disease outbreaks. UMN has also invested in creating a hub in Kampala, Uganda with administrative personnel, infrastructure to aid in research and administrative activities.
As an example of past successful training, David Boulware, a former fellow UMN Infectious Diseases fellow supported by a T32 training grant, is now a faculty member at UMN, with independent grants that look at cryptococcal antigen screening in HIV infection and improving diagnostic and neurocognitive outcomes in HIV meningitis. Similarly, David Meya, who trained with Paul Bohjanen and David Boulware at UMN, is now a faculty member at Makerere University with his own R01; Paul Bangirana, who trained at UMN, obtained the first pediatric neuropsychology degree awarded to a Ugandan scientist, and is now a Makerere University faculty member. Many grant-supported research activities at Makerere University emphasize a multidisciplinary approach to health and disease (e.g., HHV-8 and malignancy; neurobehavioral sequelae of severe malaria; iron deficiency; severe malaria and neurodevelopment; zoonotic sources of human disease outbreaks; neurologic complications of HIV), making Uganda an outstanding partner for Fogarty Fellow and Scholar training.Read more…
UCI/Hutchinson Center Cancer Alliance: In 2004, Dr. Corey Casper initiated a collaboration with Dr. Jackson Orem to develop effective prevention and treatment strategies for infection-associated cancers to benefit the millions of people in Uganda, the United States and worldwide who suffer from malignancies such as Burkitt lymphoma and Kaposi sarcoma. By working closely with Ugandan researchers and oncologists, Center researchers hope to expand their knowledge of infection-related cancers and improve cancer care in Uganda and at home. The UCI/Hutchinson Center Cancer Alliance developed a three-pronged approach for addressing the needs of cancer patients in Uganda: 1) conduct cutting-edge research in infection-related cancers to better understand the pathogenesis of these diseases in order to develop and test more effective, efficacious and safer treatment and prevention regimens; 2) improve clinical capacity through provision of medical support and revised clinical protocols for those with infectious cancers; and 3) Train clinicians and support staff to enhance local human capacity to sustain research and clinical care activities at the site.Read more…
Research Themes: Malaria Complications
- Cerebral Malaria
- Malaria and Sickle Cell Anemia
- Plasma Transfusions for Hematological Cancer Patients
- Meningitis Diagnosis, Prevention, and Treatment
For a list of projects in Uganda: click here
Current Fogarty Trainees